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Unfortunately, there was a shortage of studies evaluating the effect of Diode laser as a cavity disinfectant on the degree of microleakage at tooth- restoration interface while limited studies evaluated its effect on the bond strength or its antibacterial potentiality [10, 31, 34]

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However, it increased heart rate, cardiac output, and induced myocardial degeneration in mice and thus was terminated as a preclinical candidate ( Inhibitors of c-Met Downstream Mediators To solve the side effects mentioned above, several therapy strategies have been suggested